Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Cefdinir

C. diff Risk

High

Oral Bioavailability

Low

Approximate Cost

$1/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Pediatric

High dose
28 mg/kg/day divided q12h

Standard dose
14 mg/kg/day divided q12h

Adult

300 mg PO q12h

General Information

Common Usage

Common Usage

  • UTI

  • Upper and lower respiratory tract infections

Adverse Effects

Adverse Effects

Generally well tolerated

  • Allergic reactions

  • Diarrhea

  • Red stool with iron supplementation

  • Eosinophilia

Major Interactions

Major Interactions

Iron containing products: Cases of reddish stools have been reported with concomitant use of Cefdinir and iron-containing products due to a non-absorbable complex in the GI tract.

Pharmacology

Pharmacology

Antimicrobial class: Oral Cephalosporin - 3rd generation

Pregnancy category: B

Average serum half life: 1.7 hours

CSF penetration: minimal

Urine penetration: therapeutic

Route of Elimination: renal

Metabolism: minimal