Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Ampicillin-Sulbactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$10/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Pediatric

Adult

3 g IV q6h

Acinetobacter spp infection
Consider 3 g IV q4h

General Information

Common Usage

Common Usage

  • Bite wounds

  • Aspiration pneumonia

  • Polymicrobial SSTI and intraabdominal infections

Drug Monitoring

Drug Monitoring

Long courses: CMP, CBC weekly

First Line Indications

First Line Indications

Bite wounds prophylaxis and/or treatment

Additional Information

Additional Information

For conversion to PO use amoxicillin-clavulanate

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin Beta-lactam + beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

CSF penetration: sulbactam has poor penetration into CSF with uninflamed meninges

Route of Elimination: Urine