Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$150-200/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

2g IV q8h for severe infections

Cystic Fibrosis
2 g IV q6h

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with Penicillin and Cephalosporin anaphylaxis or when there is no alternative susceptible agent.

Specialized nebulized form used in Cystic fibrosis patients (do not use IV formulation for nebulization).

Empiric therapy for Febrile neutropenia in patients with severe Penicillin and Cephalosporin allergy - must give in combination with Vancomycin (for the gram-positive coverage).

Drug Monitoring

Drug Monitoring

Monitor liver enzymes and renal function

Adverse Effects

Adverse Effects

  •  Elevated liver enzymes

  •  Cytopenias

  •  Eosinophilia

  •  Phlebitis at injection site

  •  Rash/allergy

  •  CNS toxicity

Major Interactions

Major Interactions

No significant interactions.

Additional Information

Additional Information

Restricted to infectious diseases providers.
Verify allergies and reactions to specific agents with patient before calling.

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic