Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Penicillin VK (oral)

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

<$1/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

CrCl < 10500 mg PO q8h

Adult

500mg PO q6-8h

General Information

Common Usage

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

Drug Monitoring

  •  Monitor for allergy

  •  Periodic CBC, SCr

Adverse Effects

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

Major Interactions

No significant interactions

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic