Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$11 to $16 per day

General Information

Common Usage

  • Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas

  • Neutropenic fever

  • Used especially for nosocomial infections involving resistant organisms

Drug Monitoring

Long term: CBC, BMP weekly

Adverse Effects

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate