Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Ceftazidime

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$25/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Pediatric

Adult

Standard dosing
2g IV q8h

Cystic fibrosis
2g IV q6h

General Information

Common Usage

Common Usage

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other Cephalosporins.

Adverse Effects

Adverse Effects

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Additional Information

Additional Information

Nonformulary agent. Available for cystic fibrosis patients and ocular injections.

Pharmacology

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic