High
Excellent
Oral: <$1/day
IV: $4-7/day
Standard dosing
PO: 30-40 mg/kg/day divided q12h
IV: 30 mg/kg/day divided q8-12h
Cystic Fibrosis
PO: 40 mg/kg/day divided q12h
IV: 30 mg/kg/day divided q8h
PO: 500-750mg po q12h
IV: 400mg IV q8-12h
Note: to cover Pseudomonas use max dosing (oral 750 mg po q12 or intravenous 400 mg q8h)
Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites
QTc prolongation
Dysglycemia
Tendinopathy and rupture
GI upset
Rash
Retinal detachment
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
Cyclosporine - Increased levels of cyclosporine
Warfarin - Increased INR
Methadone - Lowered seizure threshold
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic
