Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Dicloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$2-$4/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No renal adjustment required

Adult

1 g PO TID or 500 mg PO QID

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic

CSF penetration: Limited