Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Daptomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$150-300/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

Restricted to Infectious Diseases providers

Endocarditis or bloodstream infection
8-12mg/kg IV daily

Use actual body weight. May consider adjusted body weight in morbidly obese patients.

Hepatic

Unknown for severe hepatic dysfunction

General Information

Common Usage

Common Usage

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection.

Drug Monitoring

Drug Monitoring

Creatine kinase weekly

Adverse Effects

Adverse Effects

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

  • Myopathy including rhabdomyolysis

Major Interactions

Major Interactions

Statins and fibrates - Increased myopathy. Monitor creatine kinase while on daptomycin therapy.

Additional Information

Additional Information

Higher doses used for endovascular infection.

Recommend Infectious Diseases Consult.

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Pharmacology

Pharmacology

Antimicrobial class: Cyclic Lipopeptide.

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Possible - case reports

Lung penetration: Poor

Urine penetration: Therapeutic