Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Fidaxomicin

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

$166/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

C. difficile
200mg po BID x 10days

General Information

Acceptable Uses

Acceptable Uses

Recurrent C. difficile infection or those at very high risk for recurrent C. difficile infection

Common Usage

Common Usage

C. difficile colitis

Adverse Effects

Adverse Effects

  •  GI disturbance

  •  Cytopenias

  •  Hypersensitivity: facial, tongue or throat swelling

Additional Information

Additional Information

Caution in patients with macrolide allergy (structurally similar)

Pharmacology

Pharmacology

Antimicrobial class: Specialized anti-C. difficile macrocyclic agent

Pregnancy category: B

Urine penetration: None

Lung penetration: None

CSF penetration: None

Biliary penetration: None