Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Micafungin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$60-70/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

100 mg IV daily

May consider 150 mg IV daily in morbidly obese patients

General Information

Common Usage

Common Usage

Therapy of suspected and confirmed invasive Candida infections

Adverse Effects

Adverse Effects

  •  Increased liver enzymes

  •  GI upset

Major Interactions

Major Interactions

Increases levels of sirolimus and nifedipine (mild)

Additional Information

Additional Information

Restricted to Infectious Diseases providers

Reserved for resistant Candida infections (C. glabrata, C. krusei)

Pharmacology

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 15 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

No renal adjustment required

May consider 150 mg daily for morbidly obese patients