Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Cephalexin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

<$1/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Pediatric

75 -100 mg/kg/day divided q6-8hr

Adult

1000 mg po TID

Morbid obese patient: consider 1500 mg PO TID or 1 g QID

General Information

Common Usage

Common Usage

  •  Skin and soft tissue infection

  •  MSSA infections

  • UTI

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

Major Interactions

Major Interactions

Increases metformin levels

Pharmacology

Pharmacology

Antimicrobial class: First Generation Cephalosporin.

Pregnancy category: B

Biliary penetration: Moderate

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic