Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Norfloxacin

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

400mg PO BID

General Information

Common Usage

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Additional Information

Additional Information

Nonformulary
Use ciprofloxacin instead for SBP prophylaxis

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic