Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Fosfomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$74/dose

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Inpatient use requires approval from Infectious Diseases

Complicated UTI
3g PO q2-3days x 3 doses

General Information

Common Usage

Common Usage

Urinary Tract Infection, especially involving resistant organisms such as ESBL producing organisms

Off label - Prostatitis (ID consultation recommended)

Adverse Effects

Adverse Effects

  •  GI upset, especially diarrhea

  •  Headache

  •  Eosinophilia, neutropenia

  •  Hypokalemia

Major Interactions

Major Interactions

No significant interactions

Additional Information

Additional Information

Recommended to reserve for resistant organisms such as ESBL or VRE as other treatment options are available for susceptible organisms.

Recommended to use 3 dose treatment series over single use.

Inpatient - restricted to Infectious Diseases

Pharmacology

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic