Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Linezolid

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

PO: $3/day
IV: $42/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Pediatric

Less than 12 years old30 mg/kg/day divided q8h

12 years old and older600 mg IV/PO q12h

Adult

600mg PO/IV q12h

May consider q8h dosing for Cystic Fibrosis patients with MIC 1 or greater

General Information

Common Usage

Common Usage

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.

Covers MRSA and VRE.

Drug Monitoring

Drug Monitoring

CBC at least once/week

Visual testing for therapy >3 months or if symptoms develop on therapy.

Adverse Effects

Adverse Effects

  • Serotonin syndrome

  • Rash

  • Elevated liver enzymes

  • Lactic acidosis

  • Myelosuppression (usually with >2weeks therapy)- reversible

  • Peripheral/optic neuropathy with prolonged courses

Major Interactions

Major Interactions

SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.

Rifampin decreases linezolid levels.

Additional Information

Additional Information

Restricted to Infectious Diseases

Pharmacology

Pharmacology

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic