Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Tigecycline

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Nonformulary, not stocked
$150/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

100mg IV load on day 1 then 50mg IV q12h

Hepatic

Severe Impairment - Child Pugh C
100mg load on day 1 then 25mg IV daily

General Information

Common Usage

Common Usage

M. abscessus, M. chelonae, M. fortuitum infections if patient can tolerate N/V

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Adverse Effects

Adverse Effects

Avoid or use with caution in patients with tetracycline reactions.

GI side effects very prominent with significant nausea and vomiting. Consider premedication with ondansetron.

Rash, abnormal liver enzymes, pancreatitis.

Additional Information

Additional Information

Nonformulary, not stocked.

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Pharmacology

Pharmacology

Antimicrobial class: Glycylcyline derivative

Pregnancy category: D

Average serum half life: 42 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic