Amoxicillin

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

<$1/day

Spectrum Of Activity

Dosing

500-1000mg po TID

Empiric S. pneumoniae coverage
1000mg po TID

General Information

Common Usage

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for respiratory infections and urinary tract infections.

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

Major Interactions

Allopurinol - increased rash

Additional Information

Good step down agent from IV ampicillin

Ampicillin susceptibility implies amoxicillin susceptibility

Oral amoxicillin has better tolerability and bioavailability than oral ampicillin

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Limited - use IV ampicillin for meningitis

Lung penetration: Therapeutic

Urine penetration: Therapeutic