Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Cefotaxime

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$10 to $14 per day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Adult

Nonformulary for adult. Use Ceftriaxone instead (OK to use Ceftriaxone for SBP).

General Information

Acceptable Uses

Acceptable Uses

Formulary only for pediatrics. 2018 restricted to NICU only due to ongoing dire shortage.

Unacceptable Uses

Unacceptable Uses

Adults

Common Usage

Common Usage

Empiric therapy for:

  •  Bacterial meningitis

  •  Pneumonia (in combination with a macrolide)

  •  Intra-abdominal infection including SBP

  •  Musculoskeletal i.e. septic arthritis

  •  Urinary tract infection

Drug Monitoring

Drug Monitoring

Long term: CBC and CMP weekly

Adverse Effects

Adverse Effects

  •  Rash

  •  Localized phlebitis at injection site

  •  Allergy

  •  Positive Coombs test

  •  Neutropenia

  •  Abnormalities in liver enzymes

  •  Diarrhea

  •  CDI

Additional Information

Additional Information

Prefer Ceftriaxone use in adults

Pharmacology

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic