Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Cholangitis/Cholecystitis

Most likely pathogens

Duration of therapy

Duration based upon achievement of source control (7-10 days)

Suggested regimen

Ceftriaxone 50-75 mg/kg/dose IV q24h
Maximum: 1 gram/dose

AND

Metronidazole 10 mg/kg/dose IV q8h
Maximum: 500 mg/dose

Penicillin allergy

Ceftriaxone 50-75 mg/kg/dose IV q24h
Maximum: 1 gram/dose

AND

Metronidazole 10 mg/kg/dose IV q8h
Maximum: 500 mg/dose