Meningitis, greater than or equal to 4 weeks of age

Microbiology

Duration of therapy

Meningococcus: 7 days, longer if complicated

Pneumococcus: 10-14 days, longer if complicated

Minimum 14-21 days for other organisms

Suggested regimen

Ceftriaxone 100 mg/kg/dose IV x 1 dose, then 12 hours later:
Ceftriaxone 50 mg/kg/dose IV q12h
Maximum: 2 grams/dose AND/OR 4 grams/24h

AND

Vancomycin 15 mg/kg/dose IV q6h
Maximum: 4 grams/24h prior to levels