Cerebral abscess/subdural empyema

Duration of therapy

6 weeks or longer depending on clinical and radiographic response

Suggested regimen

Ceftriaxone 100 mg/kg/dose IV x 1 dose, then 12 hours later:
Ceftriaxone 50 mg/kg/dose IV q12h
Maximum: 2 grams/dose AND/OR 4 grams/24h

AND

Vancomycin 60 mg/kg/24h IV divided q6-8h
Maximum: 4 grams/24h prior to levels

AND

Metronidazole 30 mg/kg/24h IV divided q6-8h
Maximum: 500 mg/dose

Penicillin allergy

Ceftriaxone 100 mg/kg/dose IV x 1 dose, then 12 hours later:
Ceftriaxone 50mg/kg/dose IV q12h
Maximum: 2 grams/dose AND/OR 4 grams/24h

AND

Vancomycin 60 mg/kg/24h IV divided q6-8h
Maximum: 4 grams/24h prior to levels

AND

Metronidazole 30 mg/kg/24h IV divided q6-8h
Maximum: 500 mg/dose