Stenotrophomonas maltophilia

Intrinsically resistant to beta-lactams.

TMP-SMX is probably the most reliable agent, followed by Ticarcillin-clavulanate.

Other drugs such as Ceftazidime, Aztreonam, Levofloxacin, Moxifloxacin, and Tigecycline are sometimes used if susceptible.

Minocycline has excellent in vitro activity but limited experience.