MSSA:

Anti-staphylococcal penicillins (i.e. cloxacillin) and cephalosporins (i.e. cefazolin) are optimal agents for intravenous therapy of MSSA infections.

Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines.

MRSA:

By definition resistant to cloxacillin and cephalosporins.

Susceptible to vancomycin, daptomycin, and linezolid.

Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines