Medium
NA
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Requires dose reduction in severe hepatic impairment; consult a pharmacist for dosage adjustment.
Safety and efficacy of tigecycline in neonates has not been established, therefore dosages are not available.
Optional loading dose 1.5 mg/kg as a single dose, Max 100 mg/DOSE.
Maintenance dose: Children 8-11 years: 2.4 mg/kg/DAY IV divided q12h, MAX 100 mg/DAY,
Maintenance dose: Children 12 years or older: 2 mg/kg/DAY divided q12h, Max 100 mg/DAY.
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning
Nausea, vomiting.
Tetracycline related adverse events: photosensitivity, acute pancreatitis, increased BUN, acidosis, hypophosphatemia, rash (can be severe), abnormal hepatic enzymes and/or function tests.
Permanent tooth discoloration in children < 8 years old.
Recommended Infectious Disease consult.
Documented safety concerns (increaed mortality in adult studies).
Antimicrobial class: Tetracycline derivative
Average serum half life: No pediatric data.
Adults: Single dose: 27 hours; Multiple doses: 42 hours
Route of Elimination: 22% excreted in urine as unchanged drug; 59% in feces, primarily as unchanged drug
Clearance: Reduced by 25% in patient with moderate hepatic impairment and 55% in severe hepatic impairment
