Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$30/day

Dosing

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

No dosage adjustment necessary.

Dosing is expressed in mg piperacillin component.

Serious/ documented pseudomonal infections: IV 300 to 400 mg/kg/DAY, divided q6-8h. Max dose: 16 g piperacillin/DAY.

Ratio of piperacillin : tazobactam components is 80:1

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia

Drug Monitoring

Renal and hepatic function, CBC with differential, C. difficile-associated diarrhea, hypersensitivity reactions and IV site for phlebitis.

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes