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Antimicrobials
Medium
NA
$30/day
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
No dosage adjustment necessary.
Dosing is expressed in mg piperacillin component.
Serious/ documented pseudomonal infections: IV 300 to 400 mg/kg/DAY, divided q6-8h. Max dose: 16 g piperacillin/DAY.
Ratio of piperacillin : tazobactam components is 80:1
Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia
Renal and hepatic function, CBC with differential, C. difficile-associated diarrhea, hypersensitivity reactions and IV site for phlebitis.
Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes