Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Oseltamivir

C. diff Risk

None

Oral Bioavailability

NA

Approximate Cost

$8/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Neonatal

General Pediatric

Other

Treatment should ideally begin within 48 hours.

General Information

Common Usage

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

Adverse Effects

GI upset common

Rare - Stevens Johnson Syndrome

Neuropsychiatric side effects reported

Pharmacology

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Average serum half life: No pediatric data available.
Adult: Oseltamivir phosphate: 1-3 hours, oseltamivir carboxylate: 6-10 hours

Route of Elimination: Hepatically metabolixed to >99% of oseltamivir carboxylate (active metabolite) is eliminated by renal excretion via glomerular filtration and tubular secretion