Low
NA
$1/day
Use is contraindicated in CrCl< 60 mL/min. Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
No dosage adjustment provided by manufacturer's label. Contraindicated in patients with a previous history of cholestatic jaundice or hepatic dysfunction associated with nitrofurantoin.
Prophylaxis: PO: 1-2mg/kg/DAY given once daily or divided twice daily. Max 100mg/DAY
Treatment dose: PO: 5-7 mg/kg/DAY divided QID (divide BID if using MacroBID capsules). Max 400mg/DAY
Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis.
Antimicrobial class: Nitrofuran
Average serum half life: No pediatric data.
Adults: 20 to 60 minutes and is prolonged with renal impairment
Route of Elimination: As metabolites and unchanged drug (40%) in the urine and small amounts in the bile; renal excretion is via glomerular filtration and tubular secretion
