Doxycycline

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$0.20/day

Spectrum Of Activity

Dosing

IV, PO: 2-5 mg/kg/DAY divided q12-24h. Max dose 200mg/DAY

Use caution in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth

General Information

Common Usage

Skin and soft tissue infection, Methicillin resistant staphylococcus aureus infections, community acquired pneumonia, Malaria prophylaxis, Zoonoses

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

Major Interactions

Divalent cations - decreased absorption.

Additional Information

Avoid iron, magnesium, calcium and dairy products for at least one hour before or two hours after doxycycline administration

Pharmacology

Antimicrobial class: Tetracycline

Average serum half life: No data for pediatrics.
Adults: 12 to 15 hours (usually increases to 22 to 24 hours with multiple dosing)

Route of Elimination: In the urine (23%) and feces (30%)