Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

IV-15$/d PO-4$/d

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Neonatal

IV Mild/Moderate

75-100mg/kg/DAY divided q8h. Max:1500mg/dose

IV Severe

100-200mg/kg/DAY divided in q6-8h. Max:1500mg/dose

PO Mild/Moderate

20-30mg/kg/DAY divided q12h. Max:500mg/dose

General Information

Common Usage

Common Usage

Community acquired pneumonia

Adverse Effects

Adverse Effects

Allergy (immediate & delayed), positive Coombs, cytopenias, GI upset, diarrhea, abnormal liver enzymes

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Average serum half life: Neonates: PNA≤3 days median 5.8 hours.<br> PNA ≥8 median 1.6-3.8 hours.<br> Pediatrics: 1.4-1.9 hours.

Route of Elimination: 66-100% as unchanged drug in urine by both glomerular filtration and tubular secretion