Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$60/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Neonatal

PNA 14 days or older: IV 100mg/kg/DAY divided q12h

PNA <14 days: IV: 60-100mg/kg/DAY divided q12h

General Pediatric

40 kg and greater: IV/IM 1-2g q12h

Febrile Neutropenia: IV/IM 150mg/kg/DAY divided q8h. Max: 2g/dose

40 kg and less: IV/IM 100mg/kg/DAY divided q12h. Max: 2g/dose.

General Information

Common Usage

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias.

Pharmacology

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Average serum half life:

  • Neonates: 4-5hours.

  • Children 2 months to 6 years: 1.77-1.96 hours.

  • Adult: 2 hours

Route of Elimination: At least 85% eliminated as unchanged drug in urine