Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$5/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Neonatal

IV Mild/Moderate

IV, IM 50–100mg/kg/DAY divided q8h.
Max 2g/dose

IV Severe

IV, IM 100-150mg/kg/DAY divided q8h.
Max 2g/dose

General Information

Common Usage

Common Usage

Skin and soft tissue infection (i.e. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Adverse Effects

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias.

Major Interactions

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Average serum half life: Neonates: 3-5 hours
Adults: 1.8 hours

Route of Elimination: excreted unchanged in urine