Medium
NA
$160/day
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Cystic Fibrosis: IV 150 to 200 mg/kg/DAY divided q6-8 hours. Max dose: 8 g/DAY
IV, IM 90 to 120 mg/kg/DAY divided every 6-8 hours.
Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.
Nebulized form used in cystic fibrosis patients.
Elevated liver enzymes, cytopenias, eosinophilia, phlebitis at injection site, rash/allergy, CNS toxicity, hypotension, seizures, increased SCr
Use with caution in patients with congenital or acquired arginase deficiency or other conditions where tolerance to L-Arginine may be limited.
Antimicrobial class: Monobactam
Average serum half life: Neonates:
<7 days, ≤2.5 kg: 5.5 to 9.9 hours
<7 days, >2.5 kg: 2.6 hours
1 week to 1 month: 2.4 hours
Children 2 months to 12 years: 1.7 hours
Children with cystic fibrosis: 1.3 hours
Route of Elimination: 60% to 70% excreted unchanged in the urine by active tubular secretion and glomerular filtration; 12% excreted in feces
