Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$35/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Neonatal

General Pediatric

100-200mg/kg/DAY divided q6h

Meningitis, CNS infections, endocarditis:
200-400mg/kg/DAY divided q4-6h. Max 12g/DAY.

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.

Drug Monitoring

Drug Monitoring

Renal & liver function.

CBC with differential.

Adverse Effects

Adverse Effects

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates
    PNA 2-7days: 4 hours
    PNA 8-14 days: 2.8 hours
    PNA 15-30 days: 1.7 hour

  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours

  • Excreted in bile.