Low
NA
$500+/day
Lipid Complex (Abelcet): IV: 2.5 to 5 mg/kg/DAY given as a single daily dose.
Liposomal (Ambisome): IV: 3 to 5mg/kg/DAY given as a single daily dose
Lipid Complex (Abelcet): IV 2 to 5mg/kg/DAY given as a single daily dose.
Liposomal (Ambisome): IV: 3 to 5mg/kg/DAY given as a single daily dose.
Fungicidal therapy of yeast/fungus/mold infection (not for use in urinary tract infection)
Invasive candidiasis, aspergillosis, cryptococcosis
Visceral/mucocutaneous Leishmaniasis
Induction therapy for dimorphic fungii (cocci, blasto, histo)
Renal function, fluid status, serum electrolytes (K, Mg).
Liver enzymes, CBC with differential.
Infusion related symptoms: fever/rigors/N/V/headache
Electrolyte abnormalities - hypokalemia and hypomagnesemia, loss of bicarb
Nephrotoxicity ++
Anemia
Phlebitis
Paresthesias.
Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.
Lipid formulations of AmB (Ambisome, Abelcet) are NOT interchangable.
Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms.
Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)
Average serum half life:
No pediatric data.
Liposomal: Adults: 100-153 hours (terminal half life).
Lipid Complex: Adults: 173 hours (terminal half life).
Route of Elimination: Lipid Complex: 0.9% of drug excreted in urine over 24h; effects of hepatic and renal impairment on drug disposition are unknown.
