Secondary Peritonitis/GI Perforation

A change in antimicrobial therapy should be considered in patients with hospital acquired infections who are already on antimicrobials.

Treatment of enterococci remains controversial but may be of benefit in critically ill patients.

Treatment of Candida spp is generally indicated only when they are recovered from blood or are the primary organism in the peritoneal culture.

Postoperative antibiotics for appendicitis are unnecessary unless there is clinical evidence of peritonitis, abscess, or gangrene.

Duration of therapy must be customized to the individual patient. Surgery and Infectious Diseases consultation should be considered.