Pancreatitis

Infection develops in 30-50% of patients with necrosis documented by CT scan or at the time of surgery.

Peak incidence of infection occurs in the 3rd week of disease.

Prophylactic antibiotics have been associated with a change in the spectrum of pancreatic isolates from enteric Gram-negatives to Gram-positive organisms and fungi.

There is insufficient evidence to recommend selective gut decontamination in management of pancreatitis.