Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Pathogen-Specific Therapy

Note

All doses are for adults with normal renal and hepatic function.

Consider penicillin desensitization for pathogen-specific therapy in patients with severe allergies

Penicillin Allergy

Select Pathogen

S. pneumo

  • PCN MIC ≤ 0.06 AND/OR

  • Ceftriaxone MIC < 0.5

S. pneumo

  • PCN MIC >0.1 - 1 AND

  • Ceftriaxone MIC < 1

S. pneumo

  • PCN MIC >1 AND/OR

  • Ceftriaxone MIC ≥ 1

N. meningitidis PCN susceptible
(MIC < 0.1)

H. influenzae
Non-beta lactamase producer

H. influenzae
Beta-lactamase producer

Listeria

P. aeruginosa

E. coli and other Enterobacteriaceae

S. aureus - methicillin susceptible
(MSSA)

S. aureus - methicillin resistant
(MRSA)

Coagulase-negative staphylococci

  •  Oxacillin MIC ≤ 0.25

Coagulase-negative staphylococci

  •  Oxacillin MIC > 0.25

Enterococcus