Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Penicillin Allergy

Late

Symptoms:

  • Rash (maculopapular or morbilliform or contact dermatitis)

  • Destruction of RBC, WBC, platelets

  • Serum sickness

Generally develops days to weeks into drug

Almost always occurs after 72 hours of administration

Morbilliform rashes sometimes resolve despite continued treatment

Maculopapular and morbilliform rashes generally DO NOT progress to Stevens- Johnson syndrome

Late reactions are NOT predicted by skin tests