MSSA:

• Anti-staphylococcal penicillins (i.e. cloxacillin) and cephalosporins (i.e. cefazolin) are optimal agents for intravenous therapy of MSSA infections.

• Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines.

MRSA:

• By definition resistant to cloxacillin and cephalosporins.

• Susceptible to vancomycin, daptomycin, and linezolid.

• Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines

Note
Staphylococcus resistant to oxacillin are resistant to cefazolin, cephalexin, ceftriaxone and all other beta-lactams except ceftaroline.