Generally susceptible: Penicillins, Cephalosporins, and always susceptible to Vancomycin, Levofloxacin, and Linezolid

Variably susceptible to TMP-SMX, macrolides, and clindamycin

Resistance to penicillin and cephalosporins exists which is why vancomycin is part of empiric therapy for meningitis

For invasive infections, susceptibility profiles with MIC data should be obtained