Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Isavuconazole

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Renal - Adult

No adjustment

Hepatic - Adult

Child-Pugh class A and B
No dosage adjustment required

Child-Pugh class C
Use only if benefits outweigh potential risks; limited data

Restricted Use

Infectious Diseases consult Required

General Information

Common Usage

Common Usage

Invasive Aspergillus and Invasive Mucor

Drug Monitoring

Drug Monitoring

Laboratory

  •  CBC, CMP at start weekly, then may do periodically after

Clinical

  • Liver disfunction

  •  QTc changes

  •  Hypokalemia

Adverse Effects

Adverse Effects

  • GI upset

  • Elevated liver enzymes

  • Arrhythmias

  • QTc abnormalities

  • Hypokalemia

  • Cough

  • Peripheral edema

  • Peripheral neuropathy

  • CNS side effects

  • Renal failure

Major Interactions

Major Interactions

CYP3A4 Interactions - multiple

Additional Information

Additional Information

Avoid in patients with familial short QTc syndrome