Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Dicloxacillin

C. diff Risk

Medium

Oral Bioavailability

Low

Approximate Cost

$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

250mg - 500 mg PO Q6H

Renal - Adult

No specific dose adjustment provided by the manufacturer

Hepatic - Adult

No specific dose adjustment provided by the manufacturer

Pediatric

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Drug Monitoring

Drug Monitoring

Clinical

  • Baseline and periodic CBC with differential

  • Periodic comprehensive metabolic panel (especially with prolonged therapy)

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Phlebitis at injection site in a peripheral vein

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

Major Interactions

  • Can increase methotrexate levels

  • Tetracyclines can diminish dicloxacillin activity

  • Warfarin: decreased PT/INR with concommitant dicloxacillin

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.7 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic