None
NA
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Laboratory
Clinical
Mental status changes/seizures
Hematuria reported in cases of overdose
Common
Hematologic toxicity (neutropenia > thrombocytopenia) - reversible
Carcinogenic/teratogenic
Rare
Anemia
Rash
CNS toxicity (headache, seizure, confusion)
GI intolerance
Hepatotoxicity
Imipenem/cilastatin: increase risk of seizure when given with ganciclovir/valganciclovir;
Cyclosporine and Amphotericin B: enhanced nephrotoxic effects of cyclosporine and amphotericin B when co administered with ganciclovir/valganciclovir;
Mycophenolate: increased serum concentration of ganciclovir/valganciclovir when co-adminstered.
Teratogenic/carcinogenic - avoid direct skin and/or mucous membrane contact with gancoclovir solution
Antimicrobial class: Antiviral - Synthetic Guanine Analog
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Moderate
CSF penetration: Moderate/High
Lung penetration: Moderate
Urine penetration: High
