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Guidelines
Pathogens
Antimicrobials
Low
Excellent
IV:$$$ PO:$
Mycobacterial Infections 600 mg IV/PO Q24H
Endocarditis 300 mg IV/PO Q8H
Prosthetic Device Infections 450 mg IV/PO Q12H
No dose adjustment
Prosthetic infections due to Staph aureus (in combination with other agents), Mycobacterial infections, Brucellosis
Laboratory
Clinical
Abnormal liver enzymes
Skin rash
GI intolerance
Many via CYP interactions - review specific patient medications
May turn bodily secretions reddish-orange; caution in contact lens wearers
Never use as monotherapy except in latent TB