Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

75mg PO BID x 5 days or longer in selected patients i.e. immunocompromised, critically ill

Prophylaxis dose 75mg PO daily

Renal - Adult

Adjust for CrCl < 60

Pediatric

General Information

Common Usage

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

Adverse Effects

Rare

  •  Stevens Johnson

Common

  • Nausea

  • Vomiting

Severe

  • Hypersensitivity

  • Neuropsychiatric

Additional Information

Additional Information

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID

Pharmacology

Pharmacology

Antimicrobial class: Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic