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The recommended schedule is based on the patient’s age and underlying condition.
Administration should be postponed in persons with severe acute illness.
Persons with minor acute illness, with or without fever, may be vaccinated.
Immunocompetent adults (18-64 years) at high risk of IPD due to an underlying medical condition
Chronic CSF leak
Chronic neurologic condition that may impair clearance of oral secretions
Cochlear implants
Chronic heart disease
Diabetes
Chronic kidney disease (CKD)*
Chronic liver disease, including cirrhosis from any cause*
Chronic lung disease, including asthma requiring medical care in the preceding 12 months
*Indicates patients with the highest risk of IPD
Immunocompetent adults (18-64 years) who are long term care residents, smokers, alcoholics, homeless, illicit drug users
Immunocompetent adults 65 years and older, regardless of risk factors or previous vaccination
Adults with immunocompromising condition, except HSCT
Sickle cell disease
Congenital/acquired asplenia,
Splenic dysfunction (see Section B)
Congenital immunodeficiencies involving any part of immune system
Immunocompromising therapy (steroids, chemotherapy, radiation therapy, post-organ transplant therapy)
HIV infection
Hematopoietic stem cell transplant (HSCT)
Malignant neoplasms, including leukemia, lymphoma
Nephrotic syndrome
Solid organ or islet transplant (candidate or recipient)
Adult HSCT recipients