SSTI

Empiric Antimicrobial Therapy

Piperacillin-tazobactam 4.5 IV q8h

PLUS

Vancomycin 15-20mg/kg IV q12h

CONSIDER ADDING

Clindamycin 900 mg IV q8h

If necrotizing infection or suspected Group A streptococcal infection.

Severe Beta-Lactam Allergy (Option I)

Vancomycin 15-20mg/kg IV q12h

PLUS

Gentamicin 5-7mg/kg IV q24h

PLUS

Metronidazole 500mg IV Q12h

CONSIDER ADDING

Clindamycin 900 mg IV q8h

If necrotizing infection or Group A streptococcal infection
Discontinue Metronidazole if Clindamycin added

Severe Beta-Lactam Allergy (Option II)

Meropenem 500mg IV q6h

PLUS

Vancomycin 15-20mg/kg IV q12h

CONSIDER ADDING

Clindamycin 900 mg IV q8h

If necrotizing infection or Group A streptococcal infection