Sulfamethoxazole-Trimethoprim Dosing

Adults

1 to 2 DS tabs po BID

Infants and Children

4-6 mg trimethoprim/kg po BID to a maximum of 320 mg TMP/day (or 160 mg/dose)

Neonates

Use in infants less than 2 months remains controversial – most experts believe there is no risk of kernicterus in well patients greater than 4 weeks of age, and many would also use in infants 2-4 weeks old with no signs of jaundice