Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Type IV

Mediator

T-cells

Onset

  • More than 72h

  • Usually days to weeks

Clinical Reaction

  • Contact dermatitis

  • Pustulosis

  • Eosinophilia

  • Bullous exanthems

  • Stevens-Johnson Syndrome (SJS)

  • Toxic Epidermal Necrolysis (TEN)

  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

  • Immune hepatitis
    Interstitial nephritis

Management

  • Avoid ALL ß-lactam antibiotics

  • Consider alternative antibiotics

Consult ID