Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Type III

Mediator

IgG and/or IgM complexes

Onset

  • More than 72h

  • Usually 7-21 days

Clinical Reaction

  • Serum sickness (fever, cutaneous eruptions, lymphadenopathy, arthralgias, myalgias)

  • Glomerulonephritis

  • Small vessel vasculitis

  • Drug fever

Antibody-antigen complexes can precipitate in tissues and potentially affect any end organ

Management

  • Avoid ALL ß-lactam antibiotics

  • Consider alternative antibiotics

Consult ID